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 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Monte Carlo Cellular Automata Simulation of Receptor Trafficking in Cell Signal Transduction: Tracking Dimer and Oligomer Formation) ผู้เขียน: Chontita Rattanakul, Yongwimon Lenbury สื่อสิ่งพิมพ์:pdf AbstractA cellular automata (CA) model of the signal transduction pathway mediated by calcium sensing (CaS) receptors was constructed to investigate the effects of different fractions of healthy (functional) and defective receptors. Receptor trafficking was allowed to take place leading to dimerization and oligomerization which exerted a positive impact on the receptor binding affinity. Snapshots of receptor trafficking and distribution over the cell membrane simulated by the CA model were compared with the no-trafficking case. |
หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Stability Analysis of a Mathematical Model of Atherosclerotic Plaque Development: Fibrous Cap Formation and Degradation) ผู้เขียน:Wanwarat Anlamlert, Yongwimon Lenbury, Jonathan Bell สื่อสิ่งพิมพ์:pdf AbstractAtherosclerosis is an inflammatory disease in which plaque builds up in the artery wall. The growth of atherosclerotic plaque leads to the narrowing of the blood vessel, which may result in many possible disorders, such as coronary heart disease, cardiovascular diseases, myocardial infarction and stroke. This paper proposed a mathematical model of the essential chemical processes associated with atherosclerotic plaque development, which concentrates on the formation and possible degradation of the fibrous cap. It was shown that, under suitable conditions for the system parameters, the model system admits positive solutions. Local stability of the equilibrium was proven and conditions on the system parameters provided that ensure the system’s global stability. |
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